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Mechanisms of CYP3A induction during pregnancy: studies in HepaRG cells
Activity of CYP3A, an enzyme responsible for metabolism of many marketed drugs, is induced by ~2-fold in pregnant women. Through studies in sandwich-cultured human hepatocytes (SCHH) and HepaRG cells, our laboratory has shown that this induction is likely mediated by the increase in cortisol plasma...
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| Опубликовано в: : | AAPS J |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8248763/ https://ncbi.nlm.nih.gov/pubmed/30919109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0316-z |
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