Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1

Cytochrome P450 (CYP) 26A1 and 26B1 are heme-containing enzymes responsible for metabolizing all-trans retinoic acid (at-RA). No crystal structures have been solved, and therefore homology models that provide structural information are extremely valuable for the development of inhibitors of cytochro...

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Udgivet i:J Pharmacol Exp Ther
Main Authors: Foti, Robert S., Isoherranen, Nina, Zelter, Alex, Dickmann, Leslie J., Buttrick, Brian R., Diaz, Philippe, Douguet, Dominique
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2016
Fag:
Metabolism, Transport, and Pharmacogenomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851321/
https://ncbi.nlm.nih.gov/pubmed/26937021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232637
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