Hepatic Cyp2d and Cyp26a1 mRNAs and Activities Are Increased During Mouse Pregnancy

There is considerable evidence that drug disposition is altered during human pregnancy and based on probe drug studies, CYP2D6 activity increases during human pregnancy. The aim of this study was to determine whether the changes of CYP2D6 activity observed during human pregnancy could be replicated...

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Detalhes bibliográficos
Main Authors: Topletz, Ariel R., Le, Huong N., Lee, Nora, Chapman, John D., Kelly, Edward J., Wang, Joanne, Isoherranen, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558865/
https://ncbi.nlm.nih.gov/pubmed/23150428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.049379
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