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Sampling Site Has a Critical Impact on Physiologically Based Pharmacokinetic Modeling
It has been shown that arterial (central) and venous (peripheral) plasma drug concentrations can be very different. While pharmacokinetic studies typically measure drug concentrations from the peripheral vein such as the arm vein, physiologically based pharmacokinetic (PBPK) models generally output...
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| Publicado no: | J Pharmacol Exp Ther |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6904886/ https://ncbi.nlm.nih.gov/pubmed/31604807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.262154 |
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