Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog

Por Shah, Manish B., Zhang, Qinghai, Halpert, James R.
Publicado no Int J Mol Sci (2018)

Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains

Por Shah, Manish B., Pascual, Jaime, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado em 2011

Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity

Por Shah, Manish B., Liu, Jingbao, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado no ACS Chem Biol (2017)

X-ray Crystal Structure of the Cytochrome P450 2B4 Active Site Mutant F297A in Complex with Clopidogrel: Insights into Compensatory Rearrangements of the Binding Pocket()

Por Shah, Manish B., Jang, Hyun-Hee, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado em 2013

Comparison of In Vitro Metabolism of Ticlopidine by Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4

Por Talakad, Jyothi C., Shah, Manish B., Walker, Gregory S., Xiang, Cathie, Halpert, James R., Dalvie, Deepak
Publicado em 2011

A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational States

Por Shah, Manish B., Kufareva, Irina, Pascual, Jaime, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado em 2013

Structural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6

Por Wilderman, P. Ross, Shah, Manish B., Jang, Hyun-Hee, Stout, C. David, Halpert, James R.
Publicado em 2013

Effectiveness of different irrigation techniques on smear layer removal in apical thirds of mesial root canals of permanent mandibular first molar: A scanning electron microscopic...

Por Khaord, Pranav, Amin, Aesha, Shah, Manish B, Uthappa, Roshan, Raj, Nirmal, Kachalia, Tejal, Kharod, Hiral
Publicado no J Conserv Dent (2015)

Structural Basis of Single Nucleotide Polymorphisms in Cytochrome P450 2C9

Por Maekawa, Keiko, Adachi, Motoyasu, Matsuzawa, Yumiko, Zhang, Qinghai, Kuroki, Ryota, Saito, Yoshiro, Shah, Manish B.
Publicado no Biochemistry (2017)

Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed Upon Binding Multiple Amlodipine Molecules()

Por Shah, Manish B., Wilderman, P. Ross, Pascual, Jaime, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado em 2012

Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mut...

Por Liu, Jingbao, Shah, Manish B., Zhang, Qinghai, Stout, C. David, Halpert, James R., Wilderman, P. Ross
Publicado no Biochemistry (2016)

The 2.1Å Crystal Structure of an Acyl-CoA Synthetase from Methanosarcina acetivorans reveals an alternate acyl binding pocket for small branched acyl substrates,

Por Shah, Manish B., Ingram-Smith, Cheryl, Cooper, Leroy L., Qu, Jun, Meng, Yu, Smith, Kerry S., Gulick, Andrew M.
Publicado em 2009

Structural and Biophysical Characterization of Human Cytochromes P450 2B6 and 2A6 Bound to Volatile Hydrocarbons: Analysis and Comparison

Por Shah, Manish B., Wilderman, P. Ross, Liu, Jingbao, Jang, Hyun-Hee, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado no Mol Pharmacol (2015)

Effect of Detergent Binding on Cytochrome P450 2B4 Structure as Analyzed by X-ray Crystallography and Deuterium-Exchange Mass Spectrometry

Por Shah, Manish B., Jang, Hyun-Hee, Wilderman, P. Ross, Lee, David, Li, Sheng, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado no Biophys Chem (2016)

Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xen...

Por Shah, Manish B., Liu, Jingbao, Huo, Lu, Zhang, Qinghai, Dearing, M. Denise, Wilderman, P. Ross, Szklarz, Grazyna D., Stout, C. David, Halpert, James R.
Publicado no Mol Pharmacol (2016)

Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography

Por Wilderman, P. Ross, Shah, Manish B., Liu, Tong, Li, Sheng, Hsu, Simon, Roberts, Arthur G., Goodlett, David R., Zhang, Qinghai, Woods, Virgil L., Stout, C. David, Halpert, James R.
Publicado em 2010

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-Å Resolution

Por Gay, Sean C., Shah, Manish B., Talakad, Jyothi C., Maekawa, Keiko, Roberts, Arthur G., Wilderman, P. Ross, Sun, Ling, Yang, Jane Y., Huelga, Stephanie C., Hong, Wen-Xu, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Publicado em 2010