Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism

Crystal structures of CYP2B35 and CYP2B37 from the desert woodrat were solved in complex with 4-(4-chlorophenyl)imidazole (4-CPI). The closed conformation of CYP2B35 contained two molecules of 4-CPI within the active site, whereas the CYP2B37 structure demonstrated an open conformation with three 4-...

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Publicado no:Mol Pharmacol
Main Authors: Shah, Manish B., Liu, Jingbao, Huo, Lu, Zhang, Qinghai, Dearing, M. Denise, Wilderman, P. Ross, Szklarz, Grazyna D., Stout, C. David, Halpert, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809303/
https://ncbi.nlm.nih.gov/pubmed/26826176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.102111
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