Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations

Using a combined structural and biochemical approach, the functional importance of a recently described peripheral pocket bounded by the E-, F-, G-, and I-helices in CYP2B4 and 2B6 was probed. Three series of 4-substituted-7-alkoxycoumarin derivatives with a -H, -CH(3), or -CF(3) at the 4 position o...

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Publicado en:Biochemistry
Main Authors: Liu, Jingbao, Shah, Manish B., Zhang, Qinghai, Stout, C. David, Halpert, James R., Wilderman, P. Ross
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864431/
https://ncbi.nlm.nih.gov/pubmed/26982502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01330
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