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Functional Importance of a Peripheral Pocket in Mammalian Cytochrome P450 2B Enzymes()

The functional importance of a peripheral pocket found in previously published X-ray crystal structures of CYP2B4 and CYP2B6 was probed using a biophysical approach. Introduction of tryptophan within the pocket of CYP2B4 at F202 or I241 leads to marked impairment of 7-ethoxy-4-(trifluoromethyl)couma...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Jang, Hyun-Hee, Liu, Jingbao, Lee, Ga-Young, Halpert, James R., Wilderman, P. Ross
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4599343/
https://ncbi.nlm.nih.gov/pubmed/26319176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2015.08.007
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