تحميل...

Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme

Residues located outside of the active site of cytochromes P450 2B have exhibited importance in ligand binding, structural stability, and drug metabolism. However, contributions of non-active site residues to the plasticity of these enzymes are not known. Thus, a systematic investigation was underta...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Wilderman, P. Ross, Gay, Sean C., Jang, Hyun-Hee, Zhang, Qinghai, Stout, C. David, Halpert, James R.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2011
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911823/
https://ncbi.nlm.nih.gov/pubmed/22051155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08411.x
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