Structure of the two-domain hexameric APS kinase from Thiobacillus denitrificans: structural basis for the absence of ATP sulfurylase activity

le Gay, Sean C., Segel, Irwin H., Fisher, Andrew J.
Foilsithe 2009

Structural Features of Cytochromes P450 and Ligands that Affect Drug Metabolism as Revealed by X-ray Crystallography and NMR

le Gay, Sean C., Roberts, Arthur G., Halpert, James R.
Foilsithe 2010

Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H–imidazole: ligand induced structural response through α-helical repositioning

le Gay, Sean C., Sun, Ling, Maekawa, Keiko, Halpert, James R., Stout, C. David
Foilsithe 2009

Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active site residues in protein-ligand interactions based on crystal structures of the ligand-boun...

le Wilderman, P. Ross, Gay, Sean C., Jang, Hyun-Hee, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Foilsithe 2011

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel

le Gay, Sean C., Roberts, Arthur G., Maekawa, Keiko, Talakad, Jyothi C., Hong, Wen-Xu, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Foilsithe 2010

Potent Mechanism-Based Inactivation Of Cytochrome P450 2B4 By 9-Ethynylphenanthrene: Implications For Allosteric Modulation Of Cytochrome P450 Catalysis()

le Zhang, Haoming, Gay, Sean C., Shah, Manish, Foroozesh, Maryam, Liu, Jiawang, Osawa, Yoichi, Zhang, Qinghai, Stout, C. David, Halpert, James R., Hollenberg, Paul F.
Foilsithe 2013

Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity

le Gay, Sean C., Zhang, Haoming, Wilderman, P. Ross, Roberts, Arthur G., Liu, Tong, Li, Sheng, Lin, Hsia-lien, Zhang, Qinghai, Woods, Virgil L., Stout, C. David, Hollenberg, Paul F., Halpert, James R.
Foilsithe 2011

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-Å Resolution

le Gay, Sean C., Shah, Manish B., Talakad, Jyothi C., Maekawa, Keiko, Roberts, Arthur G., Wilderman, P. Ross, Sun, Ling, Yang, Jane Y., Huelga, Stephanie C., Hong, Wen-Xu, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Foilsithe 2010