Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial Enzymatic Activity

A combined structural and computational analysis of rabbit cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene (tBPA) has yielded insight into how the enzyme retains partial activity. Since conjugation to tBPA modifies a highly conserved active site resi...

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Detalhes bibliográficos
Main Authors: Gay, Sean C., Zhang, Haoming, Wilderman, P. Ross, Roberts, Arthur G., Liu, Tong, Li, Sheng, Lin, Hsia-lien, Zhang, Qinghai, Woods, Virgil L., Stout, C. David, Hollenberg, Paul F., Halpert, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105221/
https://ncbi.nlm.nih.gov/pubmed/21510666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200482g
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