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Functional Importance of a Peripheral Pocket in Mammalian Cytochrome P450 2B Enzymes()
The functional importance of a peripheral pocket found in previously published X-ray crystal structures of CYP2B4 and CYP2B6 was probed using a biophysical approach. Introduction of tryptophan within the pocket of CYP2B4 at F202 or I241 leads to marked impairment of 7-ethoxy-4-(trifluoromethyl)couma...
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| Gepubliceerd in: | Arch Biochem Biophys |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4599343/ https://ncbi.nlm.nih.gov/pubmed/26319176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2015.08.007 |
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