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Effect of Detergent Binding on Cytochrome P450 2B4 Structure as Analyzed by X-ray Crystallography and Deuterium-Exchange Mass Spectrometry

Multiple crystal structures of CYP2B4 have demonstrated the binding of the detergent 5-cyclohexyl-1-pentyl-β-D-maltoside (CYMAL-5) in a peripheral pocket located adjacent to the active site. To explore the consequences of detergent binding, X-ray crystal structures of the peripheral pocket mutant CY...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biophys Chem
Egile Nagusiak: Shah, Manish B., Jang, Hyun-Hee, Wilderman, P. Ross, Lee, David, Li, Sheng, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983516/
https://ncbi.nlm.nih.gov/pubmed/27280734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2016.05.007
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