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Cross-linking Mass Spectrometry and Mutagenesis Confirm the Functional Importance of Surface Interactions between CYP3A4 and Holo/Apo Cytochrome b(5)
Cytochrome b(5) (cyt b(5)) is one of the key components in the microsomal cytochrome P450 monooxygenase system. Consensus has not been reached on the underlying mechanism of cyt b(5) modulation of CYP catalysis. Both cyt b(5) and apo b(5), are reported to stimulate the activity of several P450 isofo...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568533/ https://ncbi.nlm.nih.gov/pubmed/23150942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301069r |
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