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The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4()

Human cytochrome P450 3A4 (CYP3A4) metabolizes a significant portion of clinically relevant drugs and often exhibits complex steady-state kinetics that can involve homotropic and heterotropic cooperativity between bound ligands. In previous studies, the hydroxylation of the sedative midazolam (MDZ)...

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Bibliografiske detaljer
Main Authors: Roberts, Arthur G., Yang, Jing, Halpert, James R., Nelson, Sidney D., Thummel, Kenneth T., Atkins, William M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828125/
https://ncbi.nlm.nih.gov/pubmed/21992114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200924t
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