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Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5

There is growing clinical interest of thalidomide because of its immunomodulatory and antiangiogenic properties, despite its teratogenicity. However, little information about thalidomide has been reported regarding its precise effects on drug-metabolizing enzymes. We investigated the effects of thal...

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Bibliografiske detaljer
Main Authors: Okada, Yusuke, Murayama, Norie, Yanagida, Chihiro, Shimizu, Makiko, Guengerich, F. Peter, Yamazaki, Hiroshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Pharmacology and Experimental Therapeutics 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719675/
https://ncbi.nlm.nih.gov/pubmed/18948377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.024679
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