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Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5

There is growing clinical interest of thalidomide because of its immunomodulatory and antiangiogenic properties, despite its teratogenicity. However, little information about thalidomide has been reported regarding its precise effects on drug-metabolizing enzymes. We investigated the effects of thal...

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Detalhes bibliográficos
Main Authors: Okada, Yusuke, Murayama, Norie, Yanagida, Chihiro, Shimizu, Makiko, Guengerich, F. Peter, Yamazaki, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719675/
https://ncbi.nlm.nih.gov/pubmed/18948377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.024679
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