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Homotropic Cooperativity of Midazolam Metabolism by Cytochrome P450 3A4: Insight from Computational Studies
[Image: see text] Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of ∼50% clinically used drugs. Midazolam (MDZ) is a commonly used sedative drug and serves as a marker substrate for the CYP3A4 activity assessment. MDZ is metabolized by CYP3A4 to two hydroxylation products, 1′-O...
Sparad:
| I publikationen: | J Chem Inf Model |
|---|---|
| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Chemical
Society
2021
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8278384/ https://ncbi.nlm.nih.gov/pubmed/33884878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.1c00266 |
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