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Computational Insight Into Vitamin K(1) ω-Hydroxylation by Cytochrome P450 4F2
Vitamin K(1) (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids. However, the mechanism of VK1 ω-hydroxylatio...
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| Publié dans: | Front Pharmacol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Media S.A.
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6167488/ https://ncbi.nlm.nih.gov/pubmed/30319412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01065 |
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