Načítá se...
A conformationally-gated model of methadone and loperamide transport by P-glycoprotein
P-glycoprotein (Pgp) is a multidrug resistance transporter that limits the penetration of a wide range of neurotherapeutics into the brain including opioids. The diphenylpropylamine opioids methadone and loperamide are structurally similar, but loperamide has about a 4-fold higher Pgp-mediated trans...
Uloženo v:
| Vydáno v: | J Pharm Sci |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317893/ https://ncbi.nlm.nih.gov/pubmed/29499278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.02.019 |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|