Učitavanje...
A conformationally-gated model of methadone and loperamide transport by P-glycoprotein
P-glycoprotein (Pgp) is a multidrug resistance transporter that limits the penetration of a wide range of neurotherapeutics into the brain including opioids. The diphenylpropylamine opioids methadone and loperamide are structurally similar, but loperamide has about a 4-fold higher Pgp-mediated trans...
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| Izdano u: | J Pharm Sci |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317893/ https://ncbi.nlm.nih.gov/pubmed/29499278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.02.019 |
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