טוען...
A conformationally-gated model of methadone and loperamide transport by P-glycoprotein
P-glycoprotein (Pgp) is a multidrug resistance transporter that limits the penetration of a wide range of neurotherapeutics into the brain including opioids. The diphenylpropylamine opioids methadone and loperamide are structurally similar, but loperamide has about a 4-fold higher Pgp-mediated trans...
שמור ב:
| הוצא לאור ב: | J Pharm Sci |
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| Main Authors: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317893/ https://ncbi.nlm.nih.gov/pubmed/29499278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.02.019 |
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