Are Aβ and Its Derivatives Causative Agents or Innocent Bystanders in AD?

Por Robakis, Nikolaos K.
Publicado em 2010

Mechanisms of FAD neurodegeneration may be independent of Aβ

Por Robakis, Nikolaos K.
Publicado em 2010

Cell signaling abnormalities may drive neurodegeneration in Familial Alzheimer disease

Por Robakis, Nikolaos K.
Publicado em 2013

Alzheimer’s Disease: New Light on Etiology and Management

Por Robakis, Nikolaos K.
Publicado no Mt Sinai J Med (2010)

Allelic interference: a mechanism for dominant negative transmission of loss of function in the neurodegeneration of familial Alzheimer's disease

Por Robakis, Nikolaos K., Georgakopoulos, Anastasios
Publicado em 2013

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

Por Gael, Barthet, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicado em 2012

An AluI RFLP detected in the human prion protein (PrP) gene

Por Harris, Marsha S., Devine-Gage, Evelyn, Robakis, Nikolaos K.
Publicado em 1990

Presenilin1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin1 FAD mutations

Por Nikolakopoulou, Angeliki M., Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicado no Neurobiol Aging (2016)

Translational control of ribosomal protein L10 synthesis occurs prior to formation of first peptide bond

Por Robakis, Nikolaos, Meza-Basso, Luis, Brot, Nathan, Weissbach, Herbert
Publicado em 1981

Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors

Por Xu, Jindong, Litterst, Claudia, Georgakopoulos, Anastasios, Zaganas, Ioannis, Robakis, Nikolaos K.
Publicado em 2009

p120 Catenin Recruits Cadherins to γ-Secretase and Inhibits Production of Aβ Peptide

Por Kouchi, Zen, Barthet, Gael, Serban, Geo, Georgakopoulos, Anastasios, Shioi, Junichi, Robakis, Nikolaos K.
Publicado em 2009

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

Por Barthet, Gael, Shioi, Junichi, Shao, Zhiping, Ren, Yimin, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicado em 2011

Presenilin1/γ-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding prot...

Por Georgakopoulos, Anastasios, Xu, Jindong, Xu, Chijie, Mauger, Gweltas, Barthet, Gael, Robakis, Nikolaos K.
Publicado em 2011

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

Por Pimplikar, Sanjay W., Nixon, Ralph A., Robakis, Nikolaos K., Shen, Jie, Tsai, Li-Huei
Publicado em 2010

Presenilin-1/γ-Secretase Controls Glutamate Release, Tyrosine Phosphorylation, and Surface Expression of N-Methyl-d-aspartate Receptor (NMDAR) Subunit GluN2B

Por Xuan, Zhao, Barthet, Gael, Shioi, Junichi, Xu, Jindong, Georgakopoulos, Anastasios, Bruban, Julien, Robakis, Nikolaos K.
Publicado em 2013

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

Por Georgakopoulos, Anastasios, Litterst, Claudia, Ghersi, Enrico, Baki, Lia, Xu, ChiJie, Serban, Geo, Robakis, Nikolaos K
Publicado em 2006

Cadherins Mediate Both the Association between PS1 and β-Catenin and the Effects of PS1 on β-Catenin Stability*

Por Serban, Geo, Kouchi, Zen, Baki, Lia, Georgakopoulos, Anastasios, Litterst, Claudia M., Shioi, Junichi, Robakis, Nikolaos K.
Publicado em 2005

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

Por Xu, Jindong, Xilouri, Maria, Bruban, Julien, Shioi, Junichi, Shao, Zhiping, Papazoglou, Ioannis, Vekrellis, Kostas, Robakis, Nikolaos K.
Publicado em 2011

Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor*

Por Litterst, Claudia, Georgakopoulos, Anastasios, Shioi, Junichi, Ghersi, Enrico, Wisniewski, Thomas, Wang, Rong, Ludwig, Andreas, Robakis, Nikolaos K.
Publicado em 2007

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Por Baki, Lia, Shioi, Junichi, Wen, Paul, Shao, Zhiping, Schwarzman, Alexander, Gama-Sosa, Miguel, Neve, Rachael, Robakis, Nikolaos K
Publicado em 2004