Загрузка...

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

γ-Secretase inhibitors (GSIs) are drugs used in research to inhibit production of Aβ and in clinical trials to treat Alzheimer's disease (AD). They inhibit proteolytic activities of γ-secretase noncompetitively by unknown mechanisms. Here, we used cortical neuronal cultures expressing endogenou...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Barthet, Gael, Shioi, Junichi, Shao, Zhiping, Ren, Yimin, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157694/
https://ncbi.nlm.nih.gov/pubmed/21597003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-183806
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!