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Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates
γ-Secretase inhibitors (GSIs) are drugs used in research to inhibit production of Aβ and in clinical trials to treat Alzheimer's disease (AD). They inhibit proteolytic activities of γ-secretase noncompetitively by unknown mechanisms. Here, we used cortical neuronal cultures expressing endogenou...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Federation of American Societies for Experimental Biology
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3157694/ https://ncbi.nlm.nih.gov/pubmed/21597003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-183806 |
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