Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

γ-Secretase inhibitors (GSIs) are drugs used in research to inhibit production of Aβ and in clinical trials to treat Alzheimer's disease (AD). They inhibit proteolytic activities of γ-secretase noncompetitively by unknown mechanisms. Here, we used cortical neuronal cultures expressing endogenou...

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Detaylı Bibliyografya
Asıl Yazarlar: Barthet, Gael, Shioi, Junichi, Shao, Zhiping, Ren, Yimin, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Federation of American Societies for Experimental Biology 2011
Konular:
Research Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157694/
https://ncbi.nlm.nih.gov/pubmed/21597003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-183806
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