Allelic interference: a mechanism for dominant negative transmission of loss of function in the neurodegeneration of familial Alzheimer's disease

Por Robakis, Nikolaos K., Georgakopoulos, Anastasios
Publicado em 2013

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

Por Gael, Barthet, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicado em 2012

Presenilin1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin1 FAD mutations

Por Nikolakopoulou, Angeliki M., Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicado no Neurobiol Aging (2016)

Peptide EphB2/CTF2 Generated by the γ-Secretase Processing of EphB2 Receptor Promotes Tyrosine Phosphorylation and Cell Surface Localization of N-Methyl-d-aspartate Receptors

Por Xu, Jindong, Litterst, Claudia, Georgakopoulos, Anastasios, Zaganas, Ioannis, Robakis, Nikolaos K.
Publicado em 2009

p120 Catenin Recruits Cadherins to γ-Secretase and Inhibits Production of Aβ Peptide

Por Kouchi, Zen, Barthet, Gael, Serban, Geo, Georgakopoulos, Anastasios, Shioi, Junichi, Robakis, Nikolaos K.
Publicado em 2009

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

Por Barthet, Gael, Shioi, Junichi, Shao, Zhiping, Ren, Yimin, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicado em 2011

Presenilin1/γ-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding prot...

Por Georgakopoulos, Anastasios, Xu, Jindong, Xu, Chijie, Mauger, Gweltas, Barthet, Gael, Robakis, Nikolaos K.
Publicado em 2011

Presenilin-1/γ-Secretase Controls Glutamate Release, Tyrosine Phosphorylation, and Surface Expression of N-Methyl-d-aspartate Receptor (NMDAR) Subunit GluN2B

Por Xuan, Zhao, Barthet, Gael, Shioi, Junichi, Xu, Jindong, Georgakopoulos, Anastasios, Bruban, Julien, Robakis, Nikolaos K.
Publicado em 2013

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

Por Georgakopoulos, Anastasios, Litterst, Claudia, Ghersi, Enrico, Baki, Lia, Xu, ChiJie, Serban, Geo, Robakis, Nikolaos K
Publicado em 2006

Cadherins Mediate Both the Association between PS1 and β-Catenin and the Effects of PS1 on β-Catenin Stability*

Por Serban, Geo, Kouchi, Zen, Baki, Lia, Georgakopoulos, Anastasios, Litterst, Claudia M., Shioi, Junichi, Robakis, Nikolaos K.
Publicado em 2005

Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor*

Por Litterst, Claudia, Georgakopoulos, Anastasios, Shioi, Junichi, Ghersi, Enrico, Wisniewski, Thomas, Wang, Rong, Ludwig, Andreas, Robakis, Nikolaos K.
Publicado em 2007

Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation

Por Michailidis, Ioannis E., Rusinova, Radda, Georgakopoulos, Anastasios, Chen, Yibang, Iyengar, Ravi, Robakis, Nikolaos K., Logothetis, Diomedes E., Baki, Lia
Publicado em 2010

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

Por Baki, Lia, Marambaud, Philippe, Efthimiopoulos, Spiros, Georgakopoulos, Anastasios, Wen, Paul, Cui, Wen, Shioi, Junichi, Koo, Eduard, Ozawa, Masayuki, Friedrich, Victor L., Robakis, Nikolaos K.
Publicado em 2001

A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

Por Marambaud, Philippe, Shioi, Junichi, Serban, Geo, Georgakopoulos, Anastasios, Sarner, Shula, Nagy, Vanja, Baki, Lia, Wen, Paul, Efthimiopoulos, Spiros, Shao, Zhiping, Wisniewski, Thomas, Robakis, Nikolaos K.
Publicado em 2002

Presenilin mediates neuroprotective functions of efnB and BDNF and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

Por Gael, Barthet, Julie, Dunys, Shao, Zhiping, Xuan, Zhao, Ren, Ymin, Xu, Jindong, Arbez, Nicolas, Mauger, Gweltas, Bruban, Julien, Georgakopoulos, Anastasios, Shioi, Junichi, Robakis, Nikolaos K.
Publicado em 2012

Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms

Por Bruban, Julien, Voloudakis, Georgios, Huang, Qian, Kajiwara, Yuji, Al Rahim, Md, Yoon, Yonejung, Shioi, Junichi, Gama Sosa, Miguel A., Shao, Zhiping, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicado no FASEB J (2015)

Allosteric signaling through an mGlu2 and 5-HT(2A) heteromeric receptor complex and its potential contribution to schizophrenia

Por Moreno, José L., Miranda-Azpiazu, Patricia, García-Bea, Aintzane, Younkin, Jason, Cui, Meng, Kozlenkov, Alexey, Ben-Ezra, Ariel, Voloudakis, Georgios, Fakira, Amanda K., Baki, Lia, Ge, Yongchao, Georgakopoulos, Anastasios, Morón, José A., Milligan, Graeme, López-Giménez, Juan F., Robakis, Nikolaos K., Logothetis, Diomedes E., Meana, J. Javier, González-Maeso, Javier
Publicado no Sci Signal (2016)

A role for non-coding variation in schizophrenia

Por Roussos, Panos, Mitchell, Amanda C., Voloudakis, Georgios, Fullard, John F., Pothula, Venu M., Tsang, Jonathan, Stahl, Eli A., Georgakopoulos, Anastasios, Ruderfer, Douglas M., Charney, Alexander, Okada, Yukinori, Siminovitch, Katherine A., Worthington, Jane, Padyukov, Leonid, Klareskog, Lars, Gregersen, Peter K., Plenge, Robert M., Raychaudhuri, Soumya, Fromer, Menachem, Purcell, Shaun M., Brennand, Kristen J., Robakis, Nikolaos K., Schadt, Eric E., Akbarian, Schahram, Sklar, Pamela
Publicado no Cell Rep (2014)