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Cellular mechanisms of γ-secretase substrate selection, processing and toxicity
Presenilins (PSs) are catalytic components of the γ-secretase proteolytic complexes that produce Aβ and cell signaling peptides. γ-Secretase substrates are mostly membrane-bound peptides derived following proteolytic cleavage of the extracellular domain of typeI transmembrane proteins. Recent work r...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404154/ https://ncbi.nlm.nih.gov/pubmed/22622135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2012.05.006 |
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