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Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

Presenilins (PSs) are catalytic components of the γ-secretase proteolytic complexes that produce Aβ and cell signaling peptides. γ-Secretase substrates are mostly membrane-bound peptides derived following proteolytic cleavage of the extracellular domain of typeI transmembrane proteins. Recent work r...

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Autores principales: Gael, Barthet, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404154/
https://ncbi.nlm.nih.gov/pubmed/22622135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2012.05.006
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