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Cellular mechanisms of γ-secretase substrate selection, processing and toxicity
Presenilins (PSs) are catalytic components of the γ-secretase proteolytic complexes that produce Aβ and cell signaling peptides. γ-Secretase substrates are mostly membrane-bound peptides derived following proteolytic cleavage of the extracellular domain of typeI transmembrane proteins. Recent work r...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404154/ https://ncbi.nlm.nih.gov/pubmed/22622135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2012.05.006 |
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