Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

av Barthet, Gael, Shioi, Junichi, Shao, Zhiping, Ren, Yimin, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Publicerad 2011

Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling

av Baki, Lia, Neve, Rachael L., Shao, Zhiping, Shioi, Junichi, Georgakopoulos, Anastasios, Robakis, Nikolaos K
I publikationen J Neurosci (2008)

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

av Xu, Jindong, Xilouri, Maria, Bruban, Julien, Shioi, Junichi, Shao, Zhiping, Papazoglou, Ioannis, Vekrellis, Kostas, Robakis, Nikolaos K.
Publicerad 2011

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

av Baki, Lia, Shioi, Junichi, Wen, Paul, Shao, Zhiping, Schwarzman, Alexander, Gama-Sosa, Miguel, Neve, Rachael, Robakis, Nikolaos K
Publicerad 2004

Presenilin1/γ-secretase protects neurons from glucose deprivation–induced death by regulating miR-212 and PEA15

av Huang, Qian, Voloudakis, Georgios, Ren, Yimin, Yoon, Yonejung, Zhang, Emily, Kajiwara, Yuji, Shao, Zhiping, Xuan, Zhao, Lebedev, Denis, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
I publikationen FASEB J (2018)

A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

av Marambaud, Philippe, Shioi, Junichi, Serban, Geo, Georgakopoulos, Anastasios, Sarner, Shula, Nagy, Vanja, Baki, Lia, Wen, Paul, Efthimiopoulos, Spiros, Shao, Zhiping, Wisniewski, Thomas, Robakis, Nikolaos K.
Publicerad 2002

Presenilin mediates neuroprotective functions of efnB and BDNF and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

av Gael, Barthet, Julie, Dunys, Shao, Zhiping, Xuan, Zhao, Ren, Ymin, Xu, Jindong, Arbez, Nicolas, Mauger, Gweltas, Bruban, Julien, Georgakopoulos, Anastasios, Shioi, Junichi, Robakis, Nikolaos K.
Publicerad 2012

Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms

av Bruban, Julien, Voloudakis, Georgios, Huang, Qian, Kajiwara, Yuji, Al Rahim, Md, Yoon, Yonejung, Shioi, Junichi, Gama Sosa, Miguel A., Shao, Zhiping, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
I publikationen FASEB J (2015)

Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci

av Fullard, John F, Giambartolomei, Claudia, Hauberg, Mads E, Xu, Ke, Voloudakis, Georgios, Shao, Zhiping, Bare, Christopher, Dudley, Joel T, Mattheisen, Manuel, Robakis, Nikolaos K, Haroutunian, Vahram, Roussos, Panos
I publikationen Hum Mol Genet (2017)

Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci

av Fullard, John F, Giambartolomei, Claudia, Hauberg, Mads E, Xu, Ke, Voloudakis, Georgios, Shao, Zhiping, Bare, Christopher, Dudley, Joel T, Mattheisen, Manuel, Robakis, Nikolaos K, Haroutunian, Vahram, Roussos, Panos
I publikationen Hum Mol Genet (2018)

Presenilin1 familial Alzheimer disease mutants inactivate EFNB1- and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-aspa...

av Al Rahim, Md, Yoon, Yonejung, Dimovasili, Christina, Shao, Zhiping, Huang, Qian, Zhang, Emily, Kezunovic, Nebojsa, Chen, Lei, Schaffner, Adam, Huntley, George W, Ubarretxena-Belandia, Iban, Georgakopoulos, Anastasios, Robakis, Nikolaos K
I publikationen Brain Commun (2020)

PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival

av Yoon, YoneJung, Voloudakis, Georgios, Doran, Nathan, Zhang, Emily, Dimovasili, Christina, Chen, Lei, Shao, Zhiping, Darmanis, Spyros, Tang, Cheuk, Tang, Jun, Wang, Victoria X., Hof, Patrick R., Robakis, Nikolaos K., Georgakopoulos, Anastasios
I publikationen Mol Psychiatry (2020)

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

av Fullard, John F., Lee, Hao-Chih, Voloudakis, Georgios, Suo, Shengbao, Javidfar, Behnam, Shao, Zhiping, Peter, Cyril, Zhang, Wen, Jiang, Shan, Corvelo, André, Wargnier, Heather, Woodoff-Leith, Emma, Purohit, Dushyant P., Ahuja, Sadhna, Tsankova, Nadejda M., Jette, Nathalie, Hoffman, Gabriel E., Akbarian, Schahram, Fowkes, Mary, Crary, John F., Yuan, Guo-Cheng, Roussos, Panos
I publikationen Genome Med (2021)