A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

E-cadherin controls a wide array of cellular behaviors including cell–cell adhesion, differentiation and tissue development. Here we show that presenilin-1 (PS1), a protein involved in Alzheimer’s disease, controls a γ-secretase-like cleavage of E-cadherin. This cleavage is stimulated by apoptosis o...

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Bibliographic Details
Main Authors: Marambaud, Philippe, Shioi, Junichi, Serban, Geo, Georgakopoulos, Anastasios, Sarner, Shula, Nagy, Vanja, Baki, Lia, Wen, Paul, Efthimiopoulos, Spiros, Shao, Zhiping, Wisniewski, Thomas, Robakis, Nikolaos K.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125968/
https://ncbi.nlm.nih.gov/pubmed/11953314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.8.1948
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