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A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
E-cadherin controls a wide array of cellular behaviors including cell–cell adhesion, differentiation and tissue development. Here we show that presenilin-1 (PS1), a protein involved in Alzheimer’s disease, controls a γ-secretase-like cleavage of E-cadherin. This cleavage is stimulated by apoptosis o...
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| Hlavní autoři: | , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125968/ https://ncbi.nlm.nih.gov/pubmed/11953314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.8.1948 |
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