Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms

Epidermal growth factor receptor (EGFR) plays pivotal roles in cell proliferation, differentiation, and tissue development, while EGFs protect neurons from toxic insults by binding EGFR and stimulating survival signaling. Furthermore, recent evidence implicates this receptor in neurometabolic disord...

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Bibliographische Detailangaben
Veröffentlicht in:FASEB J
Hauptverfasser: Bruban, Julien, Voloudakis, Georgios, Huang, Qian, Kajiwara, Yuji, Al Rahim, Md, Yoon, Yonejung, Shioi, Junichi, Gama Sosa, Miguel A., Shao, Zhiping, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2015
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550373/
https://ncbi.nlm.nih.gov/pubmed/25985800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-270645
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