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Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms
Epidermal growth factor receptor (EGFR) plays pivotal roles in cell proliferation, differentiation, and tissue development, while EGFs protect neurons from toxic insults by binding EGFR and stimulating survival signaling. Furthermore, recent evidence implicates this receptor in neurometabolic disord...
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Publicado en: | FASEB J |
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Autores principales: | , , , , , , , , , , |
Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
Federation of American Societies for Experimental Biology
2015
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4550373/ https://ncbi.nlm.nih.gov/pubmed/25985800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-270645 |
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