Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms

Epidermal growth factor receptor (EGFR) plays pivotal roles in cell proliferation, differentiation, and tissue development, while EGFs protect neurons from toxic insults by binding EGFR and stimulating survival signaling. Furthermore, recent evidence implicates this receptor in neurometabolic disord...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:FASEB J
Prif Awduron: Bruban, Julien, Voloudakis, Georgios, Huang, Qian, Kajiwara, Yuji, Al Rahim, Md, Yoon, Yonejung, Shioi, Junichi, Gama Sosa, Miguel A., Shao, Zhiping, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Federation of American Societies for Experimental Biology 2015
Pynciau:
Research Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550373/
https://ncbi.nlm.nih.gov/pubmed/25985800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-270645
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