Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms

Epidermal growth factor receptor (EGFR) plays pivotal roles in cell proliferation, differentiation, and tissue development, while EGFs protect neurons from toxic insults by binding EGFR and stimulating survival signaling. Furthermore, recent evidence implicates this receptor in neurometabolic disord...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Bruban, Julien, Voloudakis, Georgios, Huang, Qian, Kajiwara, Yuji, Al Rahim, Md, Yoon, Yonejung, Shioi, Junichi, Gama Sosa, Miguel A., Shao, Zhiping, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2015
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550373/
https://ncbi.nlm.nih.gov/pubmed/25985800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-270645
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