Presenilin mediates neuroprotective functions of efnB and BDNF and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

Activation of EphB receptors by efnB ligands on neuronal cell surface regulates important functions including neurite outgrowth, axonal guidance and synaptic plasticity. Here we show that efnB rescues primary cortical neuronal cultures from necrotic cell death induced by glutamate excitotoxicity and...

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Detalhes bibliográficos
Main Authors: Gael, Barthet, Julie, Dunys, Shao, Zhiping, Xuan, Zhao, Ren, Ymin, Xu, Jindong, Arbez, Nicolas, Mauger, Gweltas, Bruban, Julien, Georgakopoulos, Anastasios, Shioi, Junichi, Robakis, Nikolaos K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394882/
https://ncbi.nlm.nih.gov/pubmed/22475621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.02.024
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