Ligand Binding and Calcium Influx Induce Distinct Ectodomain/γ-Secretase-processing Pathways of EphB2 Receptor*

Binding of EphB receptors to ephrinB ligands on the surface of adjacent cells initiates signaling cascades that regulate angiogenesis, axonal guidance, and neuronal plasticity. These functions require processing of EphB receptors and removal of EphB-ephrinB complexes from the cell surface, but the m...

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Detalhes bibliográficos
Main Authors: Litterst, Claudia, Georgakopoulos, Anastasios, Shioi, Junichi, Ghersi, Enrico, Wisniewski, Thomas, Wang, Rong, Ludwig, Andreas, Robakis, Nikolaos K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2007
Assuntos:
Protein Synthesis, Post-Translation Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005067/
https://ncbi.nlm.nih.gov/pubmed/17428795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M611449200
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