Presenilin1/γ-secretase protects neurons from glucose deprivation–induced death by regulating miR-212 and PEA15

Reduced cerebral glucose utilization is found in aged individuals and often is an early sign of neurodegeneration. Here, we show that under glucose deprivation (GD) conditions, decreased expression of presenilin 1 (PS1) results in decreased neuronal survival, whereas increased PS1 increases neuronal...

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Veröffentlicht in:FASEB J
Hauptverfasser: Huang, Qian, Voloudakis, Georgios, Ren, Yimin, Yoon, Yonejung, Zhang, Emily, Kajiwara, Yuji, Shao, Zhiping, Xuan, Zhao, Lebedev, Denis, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731132/
https://ncbi.nlm.nih.gov/pubmed/28855274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700447RR
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