Presenilin1/γ-secretase protects neurons from glucose deprivation–induced death by regulating miR-212 and PEA15

Reduced cerebral glucose utilization is found in aged individuals and often is an early sign of neurodegeneration. Here, we show that under glucose deprivation (GD) conditions, decreased expression of presenilin 1 (PS1) results in decreased neuronal survival, whereas increased PS1 increases neuronal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FASEB J
Egile Nagusiak: Huang, Qian, Voloudakis, Georgios, Ren, Yimin, Yoon, Yonejung, Zhang, Emily, Kajiwara, Yuji, Shao, Zhiping, Xuan, Zhao, Lebedev, Denis, Georgakopoulos, Anastasios, Robakis, Nikolaos K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Federation of American Societies for Experimental Biology 2018
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731132/
https://ncbi.nlm.nih.gov/pubmed/28855274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700447RR
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