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Presenilin1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin1 FAD mutations
Mutants of presenilin1 (PS1) increase neuronal cell death causing autosomal dominant Familial Alzheimer’s disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by...
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| Publicado no: | Neurobiol Aging |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4857890/ https://ncbi.nlm.nih.gov/pubmed/27143420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2016.02.028 |
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