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Allelic interference: a mechanism for dominant negative transmission of loss of function in the neurodegeneration of familial Alzheimer's disease
Presenilins (PSs) are catalytic components of the γ-secretase complexes that promote the ε-cleavage of cell surface proteins producing cytosolic peptides shown to function in cell signaling and gene expression. In addition, secretase cleavages at γ-sites of APP substrates produce the Aβ peptides fou...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3992934/ https://ncbi.nlm.nih.gov/pubmed/24081144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000354241 |
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