Novel therapeutic strategies targeting HIV integrase

Por Quashie, Peter K, Sloan, Richard D, Wainberg, Mark A
Publicado em 2012

The R263K mutation in HIV integrase that is selected by dolutegravir may actually prevent clinically relevant resistance to this compound

Por Wainberg, Mark, Anstett, Kaitlin, Mesplede, Thibault, Quashie, Peter, Han, Yingshan, Oliveira, Maureen
Publicado no J Int AIDS Soc (2014)

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor

Por Quashie, Peter K., Han, Ying-Shan, Hassounah, Said, Mesplède, Thibault, Wainberg, Mark A.
Publicado no PLoS One (2015)

The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

Por Wares, Melissa, Mesplède, Thibault, Quashie, Peter K, Osman, Nathan, Han, Yingshan, Wainberg, Mark A
Publicado em 2014

HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M

Por Depatureaux, Agnès, Mesplède, Thibault, Quashie, Peter, Oliveira, Maureen, Moisi, Daniela, Brenner, Bluma, Wainberg, Mark
Publicado no J Int AIDS Soc (2014)

Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

Por Osman, Nathan, Mesplède, Thibault, Quashie, Peter K., Oliveira, Maureen, Zanichelli, Veronica, Wainberg, Mark A.
Publicado no J Antimicrob Chemother (2015)

Subtype-Specific Analysis of the K65R Substitution in HIV-1 That Confers Hypersusceptibility to a Novel Nucleotide-Competing Reverse Transcriptase Inhibitor

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Quashie, Peter K., Bethell, Richard, Wainberg, Mark A.
Publicado no Antimicrob Agents Chemother (2015)

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity

Por Singhroy, Diane N, Mesplède, Thibault, Sabbah, Arielle, Quashie, Peter K, Falgueyret, Jean-Pierre, Wainberg, Mark A
Publicado em 2013

Effect of HIV-1 Integrase Resistance Mutations When Introduced into SIVmac239 on Susceptibility to Integrase Strand Transfer Inhibitors

Por Hassounah, Said A., Mesplède, Thibault, Quashie, Peter K., Oliveira, Maureen, Sandstrom, Paul A., Wainberg, Mark A.
Publicado em 2014

Compensation by the E138K Mutation in HIV-1 Reverse Transcriptase for Deficits in Viral Replication Capacity and Enzyme Processivity Associated with the M184I/V Mutations

Por Xu, Hong-Tao, Asahchop, Eugene L., Oliveira, Maureen, Quashie, Peter K., Quan, Yudong, Brenner, Bluma G., Wainberg, Mark A.
Publicado em 2011

Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

Por Quashie, Peter K., Mesplède, Thibault, Han, Ying-Shan, Oliveira, Maureen, Singhroy, Diane N., Fujiwara, Tamio, Underwood, Mark R., Wainberg, Mark A.
Publicado em 2012

Subunit-Selective Mutational Analysis and Tissue Culture Evaluations of the Interactions of the E138K and M184I Mutations in HIV-1 Reverse Transcriptase

Por Xu, Hong-Tao, Oliveira, Maureen, Quashie, Peter K., McCallum, Matthew, Han, Yingshan, Quan, Yudong, Brenner, Bluma G., Wainberg, Mark A.
Publicado em 2012

Molecular Mechanism of Antagonism between the Y181C and E138K Mutations in HIV-1 Reverse Transcriptase

Por Xu, Hong-Tao, Oliveira, Maureen, Asahchop, Eugene L., McCallum, Matthew, Quashie, Peter K., Han, Yingshan, Quan, Yudong, Wainberg, Mark A.
Publicado em 2012

Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity

Por Mesplède, Thibault, Osman, Nathan, Wares, Melissa, Quashie, Peter K., Hassounah, Said, Anstett, Kaitlin, Han, Yingshan, Singhroy, Diane N., Wainberg, Mark A.
Publicado em 2014

HIV gp120 H375 Is Unique to HIV-1 Subtype CRF01_AE and Confers Strong Resistance to the Entry Inhibitor BMS-599793, a Candidate Microbicide Drug

Por Schader, Susan M., Colby-Germinario, Susan P., Quashie, Peter K., Oliveira, Maureen, Ibanescu, Ruxandra-Ilinca, Moisi, Daniela, Mespléde, Thibault, Wainberg, Mark A.
Publicado em 2012

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

Por Mesplède, Thibault, Quashie, Peter K, Osman, Nathan, Han, Yingshan, Singhroy, Diane N, Lie, Yolanda, Petropoulos, Christos J, Huang, Wei, Wainberg, Mark A
Publicado em 2013

Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Hassounah, Said, Quashie, Peter K., Han, Yingshan, Oliveira, Maureen, Stranix, Brent R., Wainberg, Mark A.
Publicado no Antimicrob Agents Chemother (2015)

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase

Por Quashie, Peter K., Mesplède, Thibault, Han, Ying-Shan, Veres, Tamar, Osman, Nathan, Hassounah, Said, Sloan, Richard D., Xu, Hong-Tao, Wainberg, Mark A.
Publicado em 2013

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase

Por Quashie, Peter K., Mesplède, Thibault, Han, Ying-Shan, Veres, Tamar, Osman, Nathan, Hassounah, Said, Sloan, Richard D., Xu, Hong-Tao, Wainberg, Mark A.
Publicado em 2014

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase

Por Quashie, Peter K., Mesplède, Thibault, Han, Ying-Shan, Veres, Tamar, Osman, Nathan, Hassounah, Said, Sloan, Richard D., Xu, Hong-Tao, Wainberg, Mark A.
Publicado em 2014