Molecular Mechanism of Antagonism between the Y181C and E138K Mutations in HIV-1 Reverse Transcriptase

Etravirine (ETR) is an expanded-spectrum nonnucleoside reverse transcriptase inhibitor (NNRTI) approved for use as an antiretroviral agent in treatment-experienced patients. Y181C and E138K in HIV-1 RT are among 20 different drug resistance mutations associated with ETR. However, E138K can be consis...

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Main Authors: Xu, Hong-Tao, Oliveira, Maureen, Asahchop, Eugene L., McCallum, Matthew, Quashie, Peter K., Han, Yingshan, Quan, Yudong, Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497622/
https://ncbi.nlm.nih.gov/pubmed/22993165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02005-12
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