JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1

Por Quan, Yudong, Xu, Hongtao, Han, Yingshan, Mesplède, Thibault, Wainberg, Mark A.
Publicado no J Virol (2017)

The R263K mutation in HIV integrase that is selected by dolutegravir may actually prevent clinically relevant resistance to this compound

Por Wainberg, Mark, Anstett, Kaitlin, Mesplede, Thibault, Quashie, Peter, Han, Yingshan, Oliveira, Maureen
Publicado no J Int AIDS Soc (2014)

The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

Por Wares, Melissa, Mesplède, Thibault, Quashie, Peter K, Osman, Nathan, Han, Yingshan, Wainberg, Mark A
Publicado em 2014

Identification of an env-defective HIV-1 mutant capable of spontaneous reversion to a wild-type phenotype in certain T-cell lines

Por Quan, Yudong, Xu, Hongtao, Kramer, Victor G, Han, Yingshan, Sloan, Richard D, Wainberg, Mark A
Publicado no Virol J (2014)

The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration

Por Mesplède, Thibault, Leng, Jing, Pham, Hanh Thi, Liang, Jiaming, Quan, Yudong, Han, Yingshan, Wainberg, Mark A.
Publicado no mBio (2017)

The Connection Domain Mutation N348I in HIV-1 Reverse Transcriptase Enhances Resistance to Etravirine and Rilpivirine but Restricts the Emergence of the E138K Resistance Mutation b...

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Oliveira, Maureen, Han, Yingshan, Quan, Yudong, Zanichelli, Veronica, Wainberg, Mark A.
Publicado em 2014

Subunit-Selective Mutational Analysis and Tissue Culture Evaluations of the Interactions of the E138K and M184I Mutations in HIV-1 Reverse Transcriptase

Por Xu, Hong-Tao, Oliveira, Maureen, Quashie, Peter K., McCallum, Matthew, Han, Yingshan, Quan, Yudong, Brenner, Bluma G., Wainberg, Mark A.
Publicado em 2012

Molecular Mechanism of Antagonism between the Y181C and E138K Mutations in HIV-1 Reverse Transcriptase

Por Xu, Hong-Tao, Oliveira, Maureen, Asahchop, Eugene L., McCallum, Matthew, Quashie, Peter K., Han, Yingshan, Quan, Yudong, Wainberg, Mark A.
Publicado em 2012

Role of the K101E Substitution in HIV-1 Reverse Transcriptase in Resistance to Rilpivirine and Other Nonnucleoside Reverse Transcriptase Inhibitors

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Huang, Wei, Oliveira, Maureen, Han, Yingshan, Quan, Yudong, Petropoulos, Christos J., Wainberg, Mark A.
Publicado em 2013

Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity

Por Mesplède, Thibault, Osman, Nathan, Wares, Melissa, Quashie, Peter K., Hassounah, Said, Anstett, Kaitlin, Han, Yingshan, Singhroy, Diane N., Wainberg, Mark A.
Publicado em 2014

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

Por Mesplède, Thibault, Quashie, Peter K, Osman, Nathan, Han, Yingshan, Singhroy, Diane N, Lie, Yolanda, Petropoulos, Christos J, Huang, Wei, Wainberg, Mark A
Publicado em 2013

Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Hassounah, Said, Quashie, Peter K., Han, Yingshan, Oliveira, Maureen, Stranix, Brent R., Wainberg, Mark A.
Publicado no Antimicrob Agents Chemother (2015)

HIV-1 Group O Integrase Displays Lower Enzymatic Efficiency and Higher Susceptibility to Raltegravir than HIV-1 Group M Subtype B Integrase

Por Depatureaux, Agnès, Quashie, Peter K., Mesplède, Thibault, Han, Yingshan, Koubi, Hannah, Plantier, Jean-Christophe, Oliveira, Maureen, Moisi, Daniela, Brenner, Bluma, Wainberg, Mark A.
Publicado no Antimicrob Agents Chemother (2014)

Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and Their Interactions with the M184I Mutation on Defining Patterns of Resistance to Nonnucleoside Reverse Trans...

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Asahchop, Eugene L., Oliveira, Maureen, McCallum, Matthew, Schader, Susan M., Han, Yingshan, Quan, Yudong, Sarafianos, Stefan G., Wainberg, Mark A.
Publicado em 2013