Effect of Mutations at Position E138 in HIV-1 Reverse Transcriptase and Their Interactions with the M184I Mutation on Defining Patterns of Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Rilpivirine and Etravirine

Impacts of mutations at position E138 (A/G/K/Q/R/V) alone or in combination with M184I in HIV-1 reverse transcriptase (RT) were investigated. We also determined why E138K is the most prevalent nonnucleoside reverse transcriptase inhibitor mutation in patients failing rilpivirine (RPV) therapy. Recom...

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Detalhes bibliográficos
Main Authors: Xu, Hong-Tao, Colby-Germinario, Susan P., Asahchop, Eugene L., Oliveira, Maureen, McCallum, Matthew, Schader, Susan M., Han, Yingshan, Quan, Yudong, Sarafianos, Stefan G., Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697388/
https://ncbi.nlm.nih.gov/pubmed/23612196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00348-13
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