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The R263K mutation in HIV integrase that is selected by dolutegravir may actually prevent clinically relevant resistance to this compound

INTRODUCTION: Drug resistance against dolutegravir (DTG) or the nucleosides with which it has been co-administered has never been observed in patients receiving this drug in first-line therapy. In contrast, a R263K mutation that confers low-level resistance (3–4 fold) to DTG has been selected by DTG...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Int AIDS Soc
المؤلفون الرئيسيون: Wainberg, Mark, Anstett, Kaitlin, Mesplede, Thibault, Quashie, Peter, Han, Yingshan, Oliveira, Maureen
التنسيق: Artigo
اللغة:Inglês
منشور في: International AIDS Society 2014
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224880/
https://ncbi.nlm.nih.gov/pubmed/25394027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7448/IAS.17.4.19518
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