Integrase Strand Transfer Inhibitors in HIV Therapy

Por Mesplède, Thibault, Wainberg, Mark A.
Publicado em 2013

Is Resistance to Dolutegravir Possible When This Drug Is Used in First-Line Therapy?

Por Mesplède, Thibault, Wainberg, Mark A.
Publicado em 2014

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence

Por Mesplède, Thibault, Wainberg, Mark A.
Publicado no Viruses (2015)

Implications for the future of the HIV epidemic if drug resistance against dolutegravir cannot occur in first-line therapy

Por Wainberg, Mark A, Mesplede, Thibault
Publicado no J Int AIDS Soc (2015)

Will LEDGIN molecules be able to play a role in a cure for HIV infection?

Por Mesplède, Thibault, Wainberg, Mark A.
Publicado no EBioMedicine (2016)

The latest evidence for possible HIV-1 curative strategies

Por Pham, Hanh Thi, Mesplède, Thibault
Publicado no Drugs Context (2018)

What if HIV were unable to develop resistance against a new therapeutic agent?

Por Wainberg, Mark A, Mesplède, Thibault, Raffi, Francois
Publicado em 2013

Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses

Por Pham, Hanh T., Mesplède, Thibault, Wainberg, Mark A.
Publicado no Retrovirology (2016)

Combination of the R263K and M184I/V Resistance Substitutions against Dolutegravir and Lamivudine Decreases HIV Replicative Capacity

Por Singhroy, Diane N., Wainberg, Mark A., Mesplède, Thibault
Publicado no Antimicrob Agents Chemother (2015)

Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review

Por Hassounah, Said A., Mesplède, Thibault, Wainberg, Mark A.
Publicado no Pathog Immun (2016)

HIV drug resistance against strand transfer integrase inhibitors

Por Anstett, Kaitlin, Brenner, Bluma, Mesplede, Thibault, Wainberg, Mark A.
Publicado no Retrovirology (2017)

HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity

Por Anstett, Kaitlin, Brenner, Bluma, Mesplède, Thibault, Wainberg, Mark A.
Publicado no J Virol (2017)

Correction for Anstett et al., “HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity”

Por Anstett, Kaitlin, Brenner, Bluma, Mesplède, Thibault, Wainberg, Mark A.
Publicado no J Virol (2018)

The R262K Substitution Combined with H51Y in HIV-1 Subtype B Integrase Confers Low-Level Resistance against Dolutegravir

Por Cutillas, Vincent, Mesplede, Thibault, Anstett, Kaitlin, Hassounah, Said, Wainberg, Mark A.
Publicado no Antimicrob Agents Chemother (2014)

Dolutegravir Resistance Mutation R263K Cannot Coexist in Combination with Many Classical Integrase Inhibitor Resistance Substitutions

Por Anstett, Kaitlin, Mesplede, Thibault, Oliveira, Maureen, Cutillas, Vincent, Wainberg, Mark A.
Publicado no J Virol (2015)

Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level...

Por Anstett, Kaitlin, Fusco, Robert, Cutillas, Vincent, Mesplède, Thibault, Wainberg, Mark A.
Publicado no J Virol (2015)

The Combination of the R263K and T66I Resistance Substitutions in HIV-1 Integrase Is Incompatible with High-Level Viral Replication and the Development of High-Level Drug Resistanc...

Por Liang, Jiaming, Mesplède, Thibault, Oliveira, Maureen, Anstett, Kaitlin, Wainberg, Mark A.
Publicado no J Virol (2015)

Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity

Por Anstett, Kaitlin, Cutillas, Vincent, Fusco, Robert, Mesplède, Thibault, Wainberg, Mark A.
Publicado no J Antimicrob Chemother (2016)

JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1

Por Quan, Yudong, Xu, Hongtao, Han, Yingshan, Mesplède, Thibault, Wainberg, Mark A.
Publicado no J Virol (2017)

Exploring an alternative explanation for the second phase of viral decay: Infection of short-lived cells in a drug-limited compartment during HAART

Por Sanche, Steven, Mesplède, Thibault, Sheehan, Nancy L., Li, Jun, Nekka, Fahima
Publicado no PLoS One (2018)