Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase

The viral RNA-dependent RNA polymerase (RdRp) activity of the dengue virus (DENV) NS5 protein is an attractive target for drug design. Here, we report the identification of a novel class of inhibitor (i.e., an active-site metal ion chelator) that acts against DENV RdRp activity. DENV RdRp utilizes a...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Xu, Hong-Tao, Colby-Germinario, Susan P., Hassounah, Said, Quashie, Peter K., Han, Yingshan, Oliveira, Maureen, Stranix, Brent R., Wainberg, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704158/
https://ncbi.nlm.nih.gov/pubmed/26574011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02203-15
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