Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase

The viral RNA-dependent RNA polymerase (RdRp) activity of the dengue virus (DENV) NS5 protein is an attractive target for drug design. Here, we report the identification of a novel class of inhibitor (i.e., an active-site metal ion chelator) that acts against DENV RdRp activity. DENV RdRp utilizes a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Xu, Hong-Tao, Colby-Germinario, Susan P., Hassounah, Said, Quashie, Peter K., Han, Yingshan, Oliveira, Maureen, Stranix, Brent R., Wainberg, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704158/
https://ncbi.nlm.nih.gov/pubmed/26574011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02203-15
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker