Subtype-Specific Analysis of the K65R Substitution in HIV-1 That Confers Hypersusceptibility to a Novel Nucleotide-Competing Reverse Transcriptase Inhibitor

Compound A is a novel nucleotide-competing HIV-1 reverse transcriptase (RT) inhibitor (NcRTI) that selects for a unique W153L substitution that confers hypersusceptibility to tenofovir, while the K65R substitution in RT confers resistance against tenofovir and enhances susceptibility to NcRTIs. Alth...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Xu, Hong-Tao, Colby-Germinario, Susan P., Quashie, Peter K., Bethell, Richard, Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432161/
https://ncbi.nlm.nih.gov/pubmed/25779585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00315-15
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