Subtype-Specific Analysis of the K65R Substitution in HIV-1 That Confers Hypersusceptibility to a Novel Nucleotide-Competing Reverse Transcriptase Inhibitor

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Quashie, Peter K., Bethell, Richard, Wainberg, Mark A.
Publicado no Antimicrob Agents Chemother (2015)

Effects of the W153L Substitution in HIV Reverse Transcriptase on Viral Replication and Drug Resistance to Multiple Categories of Reverse Transcriptase Inhibitors

Por Xu, Hong-Tao, Colby-Germinario, Susan P., Oliveira, Maureen, Rajotte, Daniel, Bethell, Richard, Wainberg, Mark A.
Publicado em 2014

Viral Resistance in Hepatitis C Virus Genotype 1-Infected Patients Receiving the NS3 Protease Inhibitor Faldaprevir (BI 201335) in a Phase 1b Multiple-Rising-Dose Study

Por Berger, Kristi L., Lagacé, Lisette, Triki, Ibtissem, Cartier, Mireille, Marquis, Martin, Lawetz, Carol, Bethell, Richard, Scherer, Joseph, Kukolj, George
Publicado em 2013

Mutations in a Conserved Residue in the Influenza Virus Neuraminidase Active Site Decreases Sensitivity to Neu5Ac2en-Derived Inhibitors

Por McKimm-Breschkin, Jennifer L., Sahasrabudhe, Anjali, Blick, Tony J., McDonald, Mandy, Colman, Peter M., Hart, Graham J., Bethell, Richard C., Varghese, Joseph N.
Publicado em 1998

Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease

Por White, Peter W., Llinàs-Brunet, Montse, Amad, Ma'an, Bethell, Richard C., Bolger, Gordon, Cordingley, Michael G., Duan, Jianmin, Garneau, Michel, Lagacé, Lisette, Thibeault, Diane, Kukolj, George
Publicado em 2010

CD160 isoforms and regulation of CD4 and CD8 T-cell responses

Por El-Far, Mohamed, Pellerin, Charles, Pilote, Louise, Fortin, Jean-Francois, Lessard, Ivan A D, Peretz, Yoav, Wardrop, Elizabeth, Salois, Patrick, Bethell, Richard C, Cordingley, Michael G, Kukolj, George
Publicado em 2014

The Liver Partition Coefficient-Corrected Inhibitory Quotient and the Pharmacokinetic-Pharmacodynamic Relationship of Directly Acting Anti-Hepatitis C Virus Agents in Humans

Por Duan, Jianmin, Bolger, Gordon, Garneau, Michel, Amad, Ma'an, Batonga, Joëlle, Montpetit, Hélène, Otis, François, Jutras, Martin, Lapeyre, Nicole, Rhéaume, Manon, Kukolj, George, White, Peter W., Bethell, Richard C., Cordingley, Michael G.
Publicado em 2012

Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target

Por Vaillancourt, Frédéric H., Brault, Martine, Pilote, Louise, Uyttersprot, Nathalie, Gaillard, Elias T., Stoltz, James H., Knight, Brian L., Pantages, Lynn, McFarland, Mary, Breitfelder, Steffen, Chiu, Tim T., Mahrouche, Louiza, Faucher, Anne-Marie, Cartier, Mireille, Cordingley, Michael G., Bethell, Richard C., Jiang, Huiping, White, Peter W., Kukolj, George
Publicado em 2012

Hybrid Antibacterials. DNA polymerase:topoisomerase inhibitors

Por Zhi, Chengxin, Long, Zheng-yu, Manikowski, Andrzej, Comstock, Jeanne, Xu, Wei-Chu, Brown, Neal C., Tarantino, Paul M., Holm, Karsten A., Dix, Edward J., Wright, George E., Barnes, Marjorie H., Butler, Michelle M., Foster, Kimberly A., LaMarr, William A., Bachand, Benoit, Bethell, Richard, Cadilhac, Caroline, Charron, Sylvie, Lamothe, Serge, Motorina, Irina, Storer, Richard
Publicado em 2006

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

Por Fenwick, Craig, Amad, Ma'an, Bailey, Murray D., Bethell, Richard, Bös, Michael, Bonneau, Pierre, Cordingley, Michael, Coulombe, René, Duan, Jianmin, Edwards, Paul, Fader, Lee D., Faucher, Anne-Marie, Garneau, Michel, Jakalian, Araz, Kawai, Stephen, Lamorte, Louie, LaPlante, Steven, Luo, Laibin, Mason, Steve, Poupart, Marc-André, Rioux, Nathalie, Schroeder, Patricia, Simoneau, Bruno, Tremblay, Sonia, Tsantrizos, Youla, Witvrouw, Myriam, Yoakim, Christiane
Publicado em 2014

Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents

Por Draffan, Alistair G., Frey, Barbara, Pool, Brett, Gannon, Carlie, Tyndall, Edward M., Lilly, Michael, Francom, Paula, Hufton, Richard, Halim, Rosliana, Jahangiri, Saba, Bond, Silas, Nguyen, Van T. T., Jeynes, Tyrone P., Wirth, Veronika, Luttick, Angela, Tilmanis, Danielle, Thomas, Jesse D., Pryor, Melinda, Porter, Kate, Morton, Craig J., Lin, Bo, Duan, Jianmin, Kukolj, George, Simoneau, Bruno, McKercher, Ginette, Lagacé, Lisette, Amad, Ma’an, Bethell, Richard C., Tucker, Simon P.
Publicado em 2014

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

Por Fader, Lee D., Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D., Kawai, Stephen H., Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K., Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W., Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla
Publicado em 2014