The Liver Partition Coefficient-Corrected Inhibitory Quotient and the Pharmacokinetic-Pharmacodynamic Relationship of Directly Acting Anti-Hepatitis C Virus Agents in Humans

Pharmacokinetic-pharmacodynamic (PK-PD) data analyses from early hepatitis C virus (HCV) clinical trials failed to show a good correlation between the plasma inhibitory quotient (IQ) and antiviral activity of different classes of directly acting antiviral agents (DAAs). The present study explored wh...

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Main Authors: Duan, Jianmin, Bolger, Gordon, Garneau, Michel, Amad, Ma'an, Batonga, Joëlle, Montpetit, Hélène, Otis, François, Jutras, Martin, Lapeyre, Nicole, Rhéaume, Manon, Kukolj, George, White, Peter W., Bethell, Richard C., Cordingley, Michael G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457380/
https://ncbi.nlm.nih.gov/pubmed/22869578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01028-12
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