Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

BI 224436 is an HIV-1 integrase inhibitor with effective antiviral activity that acts through a mechanism that is distinct from that of integrase strand transfer inhibitors (INSTIs). This 3-quinolineacetic acid derivative series was identified using an enzymatic integrase long terminal repeat (LTR)...

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Main Authors: Fenwick, Craig, Amad, Ma'an, Bailey, Murray D., Bethell, Richard, Bös, Michael, Bonneau, Pierre, Cordingley, Michael, Coulombe, René, Duan, Jianmin, Edwards, Paul, Fader, Lee D., Faucher, Anne-Marie, Garneau, Michel, Jakalian, Araz, Kawai, Stephen, Lamorte, Louie, LaPlante, Steven, Luo, Laibin, Mason, Steve, Poupart, Marc-André, Rioux, Nathalie, Schroeder, Patricia, Simoneau, Bruno, Tremblay, Sonia, Tsantrizos, Youla, Witvrouw, Myriam, Yoakim, Christiane
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068430/
https://ncbi.nlm.nih.gov/pubmed/24663024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02719-13
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