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Effects of the W153L Substitution in HIV Reverse Transcriptase on Viral Replication and Drug Resistance to Multiple Categories of Reverse Transcriptase Inhibitors

A W153L substitution in HIV-1 reverse transcriptase (RT) was recently identified by selection with a novel nucleotide-competing RT inhibitor (NcRTI) termed compound A that is a member of the benzo[4,5]furo[3,2,d]pyrimidin-2-one NcRTI family of drugs. To investigate the impact of W153L, alone or in c...

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Autors principals: Xu, Hong-Tao, Colby-Germinario, Susan P., Oliveira, Maureen, Rajotte, Daniel, Bethell, Richard, Wainberg, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136044/
https://ncbi.nlm.nih.gov/pubmed/24867966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02729-14
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