CD160 isoforms and regulation of CD4 and CD8 T-cell responses

BACKGROUND: Coexpression of CD160 and PD-1 on HIV-specific CD8(+) T-cells defines a highly exhausted T-cell subset. CD160 binds to Herpes Virus Entry Mediator (HVEM) and blocking this interaction with HVEM antibodies reverses T-cell exhaustion. As HVEM binds both inhibitory and activatory receptors,...

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Autori principali: El-Far, Mohamed, Pellerin, Charles, Pilote, Louise, Fortin, Jean-Francois, Lessard, Ivan A D, Peretz, Yoav, Wardrop, Elizabeth, Salois, Patrick, Bethell, Richard C, Cordingley, Michael G, Kukolj, George
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163173/
https://ncbi.nlm.nih.gov/pubmed/25179432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0217-y
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